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Index > Protein center > Map1lc3b(Gene name) > Rat
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  • Map1lc3b (Gene name),
  • Microtubule-associated proteins 1A/1B light chain 3B (Protein name ),  MLP3B_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Map1lc3b(Map1alc3;Map1lc3);
    Protein name:
    Microtubule-associated proteins 1A/1B light chain 3B;
    Alternative:
    Autophagy-related ubiquitin-like modifier LC3 B;Autophagy-related protein LC3 B;MAP1A/MAP1B light chain 3 B(MAP1A/MAP1B LC3 B);MAP1 light chain 3-like protein 2;Microtubule-associated protein 1 light chain 3 beta;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. Interacts at microtubules with CABP1 (via EF-hands 1 and 2) but not with calmodulin. A calcium-dependent binding site is located at the C-terminus while a calcium-independent binding site is located at the N-terminus. Interacts with FYCO1 (via C-terminus).
    Function:
    Probably involved in formation of autophagosomal vacuoles (autophagosomes).
    Subcellular Location:
    Cytoplasm cytoskeleton Endomembrane system Lipid-anchor Cytoplasmic vesicle autophagosome membrane Lipid-anchor LC3-II binds to the autophagic membranes.
    Protein Attributes:
    Sequence length:
    142
    Sequence:
    50:
    MPSEKTFKQR | RSFEQRVEDV | RLIREQHPTK | IPVIIERYKG | EKQLPVLDKT | 
    100:
    KFLVPDHVNM | SELIKIIRRR | LQLNANQAFF | LLVNGHSMVS | VSTPISEVYE | 
    142:
    SERDEDGFLY | MVYASQETFG | TALAVTYMSA | LKATATGREP | CL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    SMR:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Microtubule-associated proteins 1A/1B light chain 3B
    Cat.:
    E2880r
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Rat Microtubule-associated proteins 1A/1B light chain 3B
    Cat.:
    E2880b
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat Microtubule-associated proteins 1A/1B light chain 3B
    Cat.:
    E2880h
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    MSDS:
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    96T
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    ELISA Kit for Rat Microtubule-associated proteins 1A/1B light chain 3B
    Cat.:
    E2880m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Microtubule-associated proteins 1A/1B light chain 3B
    Cat.:
    U2880m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Microtubule-associated proteins 1A/1B light chain 3B
    Cat.:
    U2880r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Microtubule-associated proteins 1A/1B light chain 3B
    Cat.:
    U2880b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Microtubule-associated proteins 1A/1B light chain 3B
    Cat.:
    U2880h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Microtubule-associated proteins 1A/1B light chain 3B
    Cat.:
    P2880Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Microtubule-associated proteins 1A/1B light chain 3B
    Cat.:
    P2880Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Microtubule-associated proteins 1A/1B light chain 3B
    Polyclonal Antibody for Rat Microtubule-associated proteins 1A/1B light chain 3B
    Cat.:
    P2880Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Microtubule-associated proteins 1A/1B light chain 3B
    Monoclonal Antibody for Rat Microtubule-associated proteins 1A/1B light chain 3B
    Monoclonal Antibody for Rat Microtubule-associated proteins 1A/1B light chain 3B
    Monoclonal Antibody for Rat Microtubule-associated proteins 1A/1B light chain 3B
    Protein for Rat Microtubule-associated proteins 1A/1B light chain 3B
    Protein for Rat Microtubule-associated proteins 1A/1B light chain 3B
    Protein for Rat Microtubule-associated proteins 1A/1B light chain 3B
    Protein for Rat Microtubule-associated proteins 1A/1B light chain 3B

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    Linearity
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    References
    1. 1.
      "Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B."
      Mann S.S. , Hammarback J.A.
      J. Biol. Chem.269:11492-11497(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    2. 2.
      "Cloning and characterization of rat lc3 orthologs."
      Dang Y. , Yu L. , Wu J. , Pei Y.
      Submitted (2002-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      strain: Sprague-Dawley.
      tissue: Brain.
    3. 3.
      "Rattus norvegicus microtubule-associated protein 1 light chain 3 (Map1lc3)."
      Zhou G. , Dai F. , Yu L.
      Submitted (2003-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      strain: Sprague-Dawley.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Heart.
      tissue: Pituitary.
    5. 5.
      Lubec G. , Kang S.U.
      Submitted (2007-07) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 31-37;IDENTIFICATION BY MASS SPECTROMETRY
      strain: Sprague-Dawley.
      tissue: Brain.
    6. 6.
      "LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing."
      Kabeya Y. , Mizushima N. , Ueno T. , Yamamoto A. , Kirisako T. , Noda T. , Kominami E. , Ohsumi Y. , Yoshimori T.
      EMBO J.19:5720-5728(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;CLEAVAGE;MUTAGENESIS OF GLY-120
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    8. 8.
      "Caldendrin but not calmodulin binds to light chain 3 of MAP1A/B: an association with the microtubule cytoskeleton highlighting exclusive binding partners for neuronal Ca(2+)-sensor proteins."
      Seidenbecher C.I. , Landwehr M. , Smalla K.H. , Kreutz M. , Dieterich D.C. , Zuschratter W. , Reissner C. , Hammarback J.A. , Bockers T.M. , Gundelfinger E.D. , Kreutz M.R.
      J. Mol. Biol.336:957-970(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CABP1
    9. 9.
      "Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy."
      Sugawara K. , Suzuki N.N. , Fujioka Y. , Mizushima N. , Ohsumi Y. , Inagaki F.
      J. Biol. Chem.280:40058-40065(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE BY ATG4B;MUTAGENESIS OF GLN-116; PHE-119 AND GLY-120
    10. 10.
      "Effects of RNA interference of Atg4B on the limited proteolysis of LC3 in PC12 cells and expression of Atg4B in various rat tissues."
      Yoshimura K. , Shibata M. , Koike M. , Gotoh K. , Fukaya M. , Watanabe M. , Uchiyama Y.
      Autophagy2:200-208(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE BY ATG4B
    11. 11.
      "The crystal structure of microtubule-associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8."
      Sugawara K. , Suzuki N.N. , Fujioka Y. , Mizushima N. , Ohsumi Y. , Inagaki F.
      Genes Cells9:611-618(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 1-120
    12. 12.
      "The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy."
      Satoo K. , Noda N.N. , Kumeta H. , Fujioka Y. , Mizushima N. , Ohsumi Y. , Inagaki F.
      EMBO J.28:1341-1350(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 1-124 IN COMPLEX WITH ATG4B
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